Gpnmb fibrosis
WebMay 25, 2024 · GPNMB showed a dose-dependent up-regulation both acutely and after subchronic dosing. GPNMB up-regulation correlated with an increased Thr 172 -phosphorylation of AMPK in liver and quadriceps muscle in rats. Conclusion GPNMB has been identified as a translatable target engagement biomarker for use in clinical studies. WebJul 2, 2024 · Identifying the unique fibrogenic macrophages that are found in human fibrotic tissues could lead to new and more effective treatments for fibrosis. Here we used human liver and lung single cell RNA sequencing datasets to identify a unique subset of CD9 + TREM2 + macrophages expressing SPP1, GPNMB, FABP5, and CD63 with strong pro …
Gpnmb fibrosis
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WebJul 29, 2024 · GPNMB is highly expressed in some tumors, such as melanoma, glioma, breast cancer (including triple-negative neoplasia), and cholangiocarcinoma, and it has been implicated in tumor progression and ... WebsGPNMB inhibits SSc fibrosis in vitro. (A) sGPNMB significantly reduced COL1 and αSMA expression in dcSSc fibroblasts at various doses. (B) sGPNMB downregulated COL1A1 and ACTA2 at the mRNA level in dcSSc fibroblasts. (C) sGPNMB significantly reduced cell proliferation of dcSSc fibroblasts at a dose-dependent manner.
WebTGFβ downregulated GPNMB and decreased the release of its soluble form in normal fibroblasts. In dcSSc fibroblasts, GPNMB is upregulated by its own soluble form. Our data demonstrate an... WebNov 13, 2012 · This CD11B(hi) F4/80(int) Ly-6C(lo) macrophage subset was most abundant in livers during maximal fibrosis resolution and represented the principle matrix metalloproteinase (MMP) -expressing subset. Depletion of this population in CD11B promoter-diphtheria toxin receptor (CD11B-DTR) transgenic mice caused a failure of …
WebOct 25, 2016 · Our microarray-based screening in rat hearts 24 h after myocardial infarction (MI) yielded glycoprotein nonmetastatic melanoma protein B (GPNMB), which is known to be involved in inflammation and fibrosis after tissue injury. However, its role in the heart was elusive. We found increased cardiac expression levels of GPNMB in rats and mice … WebPulmonary fibrosis is characterized by the excessive deposition of extracellular matrix in the interstitium, resulting in respiratory failure. The role of remodeling mediators such as metalloproteinases (MMPs) and their inhibitors (TIMPs) …
WebFeb 15, 2024 · Pulmonary fibrosis (PF) is a form of progressive lung disease characterized by chronic inflammation and excessive extracellular matrix (ECM) deposition. The …
WebSep 1, 2024 · GPNMB knockout in CD11b + Gr1 + cells, or injection of an anti-GPNMB monoclonal Ab (mAb), abrogated CD11b + Gr1 + cell expansion, impaired T cell … cesko na koleWebAug 8, 2024 · Importantly, hepatic Trem2 and Gpnmb mRNA expression was strongly associated with liver injury and fibrosis in a cohort of mice with varying NASH severity (Xiong et al., 2024) (Figures 4 F and S4 C). To confirm the emergence of NAMs during NASH pathogenesis, we performed flow cytometry using GPNMB and CD9 antibodies to … cesko na taliriWebJun 6, 2024 · We show that GPNMB, which encodes transmembrane protein capable of shedding its ectodomain into circulation, as a previously unrecognized factor … ceskolipska gymnaziumWebSep 16, 2024 · In that model, deletion of GPNMB led to an increase in metalloproteinases 19 (MMP19) and fibrinolysis (Kumagai et al., 2015), suggesting that high expression of GPNMB might be important in regulation of fibrosis driven by HO-1 deficiency in Mϕ. Interestingly, this was accompanied by increased Marco expression, a scavenger … česko na prvnim misteWebMar 24, 2024 · Pulmonary fibrosis (PF) is a form of progressive lung disease characterized by chronic inflammation and excessive extracellular matrix (ECM) deposition. The … cesko mapa krajeWebMay 6, 2024 · A previous study has demonstrated that GPNMB-deficient mice develop more severe liver injury and fibrosis after feeding of a high-fat, high-fructose diet 11, whereas transgenic overexpression of ... cesko na mapeWebDec 15, 2024 · Osteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great potential in the treatment … ceskoplatikartou