WebApr 12, 2024 · Mechanistically, involucrasin A significantly inhibited the phosphorylation of Akt and murine double minute 2 homologue (MDM2), which resulted in increased intracellular levels of p53. This was reversed by exogenous expression of the constitutively active form of Akt. WebMar 22, 2002 · MDM2, which is known as a negative regulator of p53 function (Momand et al., 1992), is one of the substrates cleaved by caspases during apoptosis (Nicholson and Thornberry, 1997; Erhardt et al ...
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WebApr 10, 2024 · Mdm2 promotes the ubiquitination and degradation of p53, while Mdm2-p60 can bind to p53 and reduce the Mdm2-induced p53 ubiquitination to improve its … WebSep 5, 1997 · We present evidence that the mdm2 oncoprotein is cleaved by an interleukin 1beta-converting enzyme-like protease (caspase) during p53-mediated apoptosis. The … plaster rock home hardware
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WebApr 10, 2024 · However, it stabilizes p53 through competition with MDM2 ; ... The levels of cleaved PARP were examined by Western blot analysis in (A) HepG2, (B) Hep3B, (C) BxPC-3, and (D) AsPC-1 cells. (E) Cell apoptosis evaluated by annexin V and PI staining. Gradual increases in percentages of total apoptosis (early apoptosis + late apoptosis) as … WebWe present evidence that the mdm2 oncoprotein is cleaved by an interleukin 1β-converting enzyme-like protease (caspase) during p53-mediated apoptosis. The protease that … WebAug 15, 2024 · TRIM67 overexpression increased MDM2 at mRNA level, but had no effect on MDM2 protein expression (Fig. 3E and F). Notably, overexpression of TRIM67 induced MDM2 cleavage in the nucleus, generating a 60-kDa fragment and leading to the loss of C-terminal RING domain responsible for p53 ubiquitination activity (Fig. 3F and H; refs. 18, … plaster rock legion